Fresh analysis suggests that individuals who discontinue new slimming jabs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who end traditional diet and exercise programs.
Findings released in a prominent medical journal shows that while obese people often shed about a fifth of their total mass while using the jabs, the mass returns at an estimated rate of 0.8 kg per month once they quit.
"People using such treatments must be cognizant of the potential of quick weight regain when the therapy concludes," cautioned expert Dr. Susan Jebb.
Such speed of recovery implies a reversion to original mass in about 18 months.
Comparing Therapies
The research, which looked at 37 of trials involving thousands of patients, compared the results of these new drugs with conventional dieting.
Researchers emphasize that people who lose weight through diet and exercise typically experience a less rapid creep back—perhaps 0.1 kg a month—after stopping.
Explaining the Quick Rebound
Experts suggest the way of the injections explains the amplified rebound.
These medications mimic a body's own chemical called GLP-1, which helps regulate feelings of fullness.
"Long-term administration of GLP-1 levels several times higher than the body's typical production may cause the system to produce less of its endogenous hormone, and could diminish responsiveness to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this GLP-1 'fix' means appetite is unsuppressed, making binge eating a significant risk."
An Ongoing Disease?
Medical guidelines suggest the injections for people with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals say that, considering the significant potential of relapse, the treatment should be considered ongoing.
This opinion is echoed by pharmaceutical companies, who note that the results "highlight the chronic character of obesity," akin to managing conditions like high blood pressure.
User Accounts
Users who have come off the jabs explain a sudden return of appetite.
"It felt as if a switch activating and you're instantly starving," recalled a patient.
The struggle is compounded if individuals have not developed lasting lifestyle or habit modifications during therapy.
Growing Interest
Recent estimates indicate that a significant number of people in the UK have used these injections in the last 12 months, with desire remaining high.
- Adoption is greater among women compared to males.
- The middle-aged age group shows the highest usage rates.
- A large proportion obtain the medications through private prescriptions rather than public health services.
Ultimately, researchers emphasize that while GLP-1 drugs are effective agents for shedding pounds, they are not a magic cure and long-term success likely depends on ongoing behavioural changes.
